Cardiac & Renal Drugs
DRUG
|
MoA
|
USE
|
SE
|
Thiazide
|
|
USE
|
CI: gout, hyperuricemia
|
Lasix / Furosemide
|
|
|
Ototoxicity, hypokalemia, hypoMg, hypoCl, and metabolic alkalosis; contraindicaitons: sulfa allergy, hepatorenal syndrome, and edema from nephrotic syndrome
|
Glucagon
|
|
|
HypoK
HyperGLU |
Labetalol
|
|
|
Nitroglycerin
|
|
|
HA, methemoglobinemia
that causes cyanosis with nl ABG. Tx: methylene blue
CI: ↑ ICP, and closed-angle glaucoma |
Sodium Nitroprusside
|
|
|
Cyanide
toxicity (in smokers
with ↓ thiosulfate (Cn converted → thiocyanate in liver and is excreted
from kidneys. Sx: HA, nausea, vomiting, weakness, hypotension, lactic acidosis, tolerance. Keep cyanide < 5mg/ml; prevent with thiocyanate infusion- but thiocyante toxic: renal failure, MS Ds.
CI: B12 deficiency, renal failure |
Trimethaphan
|
|
Digoxin
|
|
USE
|
Dysrhythmias, AV block
Tx: K+, Mg2+, Lidocaine, charcoal, digoxin Ab |