MoA: defect in Ca++ release channel (ryanoidine receptor) with ↑ Ca++ from SR
Sx: muscle rigidity / metabolism --> Hyperthermia (↑ 1º every 5 min and may reach 110ºF, 50%) ↑ O2 use and lactate production → acidosis Tachycardia, dysrhythmia, HTN or hypotension, hyperventilation, hyperkalemia ↑↑ serum CK, myoglobinuria, and renal failure
Pr: 70% mortality without treatment, 7% if treated
Tx: D/c anesthesia, active cooling, hydration, iv bicarb Dantrolene (MoA: ↓ Ca++ release from the SR. 2.5 mg/kg IV q 15 min then 2 mg/kg PO QID x 3 days.
Epi: 1 / 15,000 anesthesia procedures
Gen: AD. Dx high risk pts w/ contracture test (expose to caffeine or halothane --> mm contraction)