- Group A (classic medullo): WNT, loss of chrom 8, CTNNB1 mutations, older children, better prognosis
Group B (nodular / desmoplastic medullo): SHH, SMO, SUFU mutations, MYC amplification, 9q deletion
Both C/D (anaplastic, large cell): OTX2, FOXG1, i(17q), 1X, -18, MYC amplification
Group C: poor prognosis
Group D: intermediate prognosis (2-2 expression of neuronal and photoreceptor markers)
- MycN - different primary vs. mets.
Myc - same primary & mets