Fx: migrate into CNS --> proliferation, infiltration --> phagocytosis and antigen presentation --> converge on foci of damage --> form microglial nodules
Cl: bipolar, tripolar, or more extensively branched
DDx: closely related to CNS macrophages or “glitter cells”
Im: lectin
Microglial Nodules
Ch: rod cells, cigar shaped nuclei
Im: CD 68+
o “Neurophonagia” – aggregation of microglia and macrophages around dying neuron
Neuronophagia:
Microglial nodules + macrophages
Microglia
Big arrow: viral inclusion body. Small arrow: microglial nodule